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VANCOUVER, BC / ACCESS Newswire / December 31, 2025 / Goldgroup Mining Inc. (‘Goldgroup‘ or the ‘Company‘) (TSXV:GGA,OTC:GGAZF)(OTCQX:GGAZF).

Goldgroup announces that, subject to the final approval of the TSX Venture Exchange (the ‘TSXV‘), it has entered into an agreement with a private arm’s length British Columbia company under which it has agreed to sell all of the issued and outstanding Class ‘A’ shares and Class ‘B’ common shares in the capital (collectively the ‘Apolo Shares‘) of Minera Apolo, S.A. de C.V. (‘Apolo‘), which owns all the issued and outstanding shares of Minera Catanava, S.A. de C.V. (‘MC‘). Apolo and MC collectively hold a 100% interest in the Pinos gold/silver project (‘Pinos‘) located in Zacatecas State, the second largest mining state in Mexico. Pinos comprises 30 contiguous mining concessions over 3,816 hectares. The sale of Apolo is an Arm’s Length Transaction and there are no finder’s fees payable.

Ralph Shearing, Chief Executive Officer, commented: ‘Having received an unsolicited bid for Pinos, management determined that it would be the best use of the Company’s resources to dispose of the Pinos asset based on the Company’s recent acquisition of the San Francisco gold mine, which is a much larger and more advanced project than Pinos. The Company’s focus will be the continued development and optimization of our flagship Cerro Prieto heap-leach gold mine and advancing towards a re-start of gold production at the San Francisco gold mine (see news release dated December 24, 2025). Both assets are located within 44km in a straight line from each other in the state of Sonora, Mexico. The San Francisco gold mine represents a unique opportunity to consolidate a highly prospective gold district.’ Mr. Shearing further stated: ‘At this stage of our Company’s development, with Pinos being a non-core asset, management and the board of directors has elected to monetize Pinos with an attractive, high cash purchase offer, deploying the sale proceeds towards Cerro Prieto optimization and re-starting gold production at San Francisco.

Under the terms of the Share Purchase Agreement, Goldgroup has agreed to sell all the Apolo Shares to a private arm’s length British Columbia company (the ‘Purchaser‘) in consideration of the payment to Goldgroup of US$5,000,000 in stages, with US$2,450,000 deposit payable on signing which will be refunded if the transaction does not close by February 16, 2026, US$550,000 to be paid on closing and US$2,000,000 to be secured by a Promissory Note and paid on or before the date that is six (6) months from the Closing Date. Further, the Purchaser has agreed to assume any and all liabilities of Goldgroup associated with Apolo, MC and the Pinos project, including the assumption of US$400,000 remaining payable on the original purchase agreement in addition to debt in the amount of US$1,500,000 payable to the previous owners of Apolo that will be triggered by the sale of Apolo. Goldgroup, the Purchaser and the previous owners of Apolo have also agreed to enter an Assumption and Acknowledgement Agreement under which the previous owners acknowledge and agree that they will have no further recourse against Goldgroup for any liabilities related to Apolo, MC and the Pinos project, all of which have been assumed by the Purchaser.

Cautionary Statement
The closing of the sale of Apolo is subject to the approval of the TSX Venture Exchange.

Clarification regarding Investor Relations Agreement
At the request of the TSXV, Goldgroup wishes to clarify its news release of October 13, 2025, regarding the retention of Machai Capital Inc. to provide digital marketing services on behalf of the Company. Goldgroup advises that it paid Machai Capital Inc. $200,000 as an upfront fee. Further Goldgroup advises that neither Machai Capital Inc. nor its principal Suneal Sandhu owned any securities of Goldgroup as at October 13, 2025.

About Goldgroup
Goldgroup is a Canadian-based mining Company with two high-growth gold assets in Mexico. In addition to the San Francisco gold mine, the Company has a 100% interest in the producing Cerro Prieto heap-leach gold mine located in the State of Sonora. An optimization and exploration program is underway at Cerro Prieto to significantly increase existing production and resources. The acquisition of Molimentales del Noroeste, S.A. de C.V. (‘Molimentales‘), the owner of the San Francisco gold mine is subject to final approval from the TSXV.

Goldgroup is led by a team of highly successful and seasoned individuals with extensive expertise in mine development, corporate finance, and exploration in Mexico.

For further information on Goldgroup, please visit www.goldgroupmining.com

On behalf of the Board of Directors

‘Ralph Shearing’
Ralph Shearing, CEO

For more information:
+1 (604) 306-6867
410 – 1111 Melville St.
Vancouver, BC, V6E 3V6
www.goldgroupmining.com
ir@goldgroupmining.com

Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this press release.

CAUTIONARY NOTES REGARDING FORWARD-LOOKING INFORMATION
Certain information contained in this news release, including any information relating to future financial or operating performance, may be considered ‘forward-looking information’ (within the meaning of applicable Canadian securities law) and ‘forward-looking statements’ (within the meaning of the United States Private Securities Litigation Reform Act of 1995). These statements relate to analyses and other information that are based on forecasts of future results, estimates of amounts not yet determinable and assumptions of management. Actual results could differ materially from the conclusions, forecasts and projections contained in such forward-looking information.

These forward-looking statements reflect Goldgroup’s current internal projections, expectations or beliefs and are based on information currently available to Goldgroup. In some cases forward-looking information can be identified by terminology such as ‘may’, ‘will’, ‘should’, ‘expect’, ‘intend’, ‘plan’, ‘anticipate’, ‘believe’, ‘estimate’, ‘projects’, ‘potential’, ‘scheduled’, ‘forecast’, ‘budget’ or the negative of those terms or other comparable terminology. Such forward-looking statements involve known and unknown risks, uncertainties and other factors which may cause actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements.

Forward-looking information is subject to a variety of known and unknown risks, uncertainties and other factors that could cause actual events or results to materially differ from those reflected in the forward-looking information, and are developed based on assumptions about such risks, uncertainties and other factors including, without limitation: receipt of all required TSXV, regulatory and other interested party approvals in connection with the Concurso Mercantilprocess; uncertainties related to actual capital costs operating costs and expenditures; production schedules and economic returns from Goldgroup’s projects; timing to integrate acquisitions (San Francisco Mine) and timing to complete additional exploration and technical reports; uncertainties associated with development activities; uncertainties inherent in the estimation of mineral resources and precious metal recoveries; uncertainties related to current global economic conditions; fluctuations in precious and base metal prices; uncertainties related to the availability of future financing; potential difficulties with joint venture partners; risks that Goldgroup’s title to its property could be challenged; political and country risk; risks associated with Goldgroup being subject to government regulation; risks associated with surface rights; environmental risks; Goldgroup’s need to attract and retain qualified personnel; risks associated with potential conflicts of interest; Goldgroup’s lack of experience in overseeing the construction of a mining project; risks related to the integration of businesses and assets acquired by Goldgroup; uncertainties related to the competitiveness of the mining industry; risk associated with theft; risk of water shortages and risks associated with competition for water; uninsured risks and inadequate insurance coverage; risks associated with potential legal proceedings; risks associated with community relations; outside contractor risks; risks related to archaeological sites; foreign currency risks; risks associated with security and human rights; and risks related to the need for reclamation activities on Goldgroup’s properties, as well as the risk factors disclosed in Goldgroup’s MD&A. Any and all of the forward-looking information contained in this news release is qualified by these cautionary statements.

Although Goldgroup believes that the forward-looking information contained in this news release is based on reasonable assumptions, readers cannot be assured that actual results will be consistent with such statements. Accordingly, readers are cautioned against placing undue reliance on forward-looking information. Goldgroup expressly disclaims any intention or obligation to update or revise any forward-looking information, whether as a result of new information, events or otherwise, except as may be required by, and in accordance with, applicable securities laws.

SOURCE: Goldgroup Mining, Inc.

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Rio Silver Inc. (‘Rio Silver’ or the ‘Company’) is pleased to announce that it has settled an aggregate of $293,250 of indebtedness (the ‘Debts’) through (1) the issuance of an aggregate of 1,396,428 common shares of the Company at a deemed issuance price of $0.21 per share, of which 976,190 shares were issued to non-arm’s length creditors; and (2) the issuance of an aggregate of 420,238 common share purchase warrants entitling the holders to purchase an aggregate of 420,238 common shares of the Company at a price of $0.28 per share until December 31, 2028, none of which share purchase warrants were issued to non-arm’s length creditors. All common shares and share purchase warrants issued to settle the Debts will be subject to a hold period expiring May 1, 2026. Completion of the securities for debt transaction will allow the Company to improve its current working capital deficiency position.

About Rio Silver Inc.

Rio Silver Inc. (TSX-V: RYO | OTC: RYOOF) is a Canadian resource company advancing high-grade, silver-dominant assets in Peru, the world’s second-largest silver producer. The Company is focused on near-term development opportunities within proven mineral belts and is supported by a seasoned technical and operational team with deep experience in Peruvian geology, underground mining, and district-scale exploration. With a clear development strategy, and a growing portfolio of highly prospective silver assets, Rio Silver is establishing the foundation to become one of Peru’s next emerging silver producers. Learn more at www.riosilverinc.com.

ON BEHALF OF THE BOARD OF DIRECTORS OF Rio Silver INC.

Chris Verrico
President, Chief Executive Officer and a Director

To learn more or engage directly with the Company, please contact:

Christopher Verrico, President and CEO
Tel: (604) 762-4448
Email: chris.verrico@riosilverinc.com
Website: www.riosilverinc.com

Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

Cautionary Note Regarding Forward-Looking Information: This news release includes forward-looking statements that are subject to risks and uncertainties. All statements within, other than statements of historical fact, are to be considered forward looking. Although the Company believes the expectations expressed in such forward-looking statements are based on reasonable assumptions, such statements are not guarantees of future performance and actual results or developments may differ materially from those in forward-looking statements. Factors that could cause actual results to differ materially from those in forward-looking statements include market prices, exploitation and exploration successes, continued availability of capital and financing, and general economic, market or business conditions. There can be no assurances that such statements will prove accurate and, therefore, readers are advised to rely on their own evaluation of such uncertainties. We do not assume any obligation to update any forward-looking statements.

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Zinc companies were supported in 2025 as prices rebounded during the second half of the year and, by the end of December, had crossed above US$3,000 per metric ton.

However, the metal still faces headwinds, as its biggest demand driver is its use in the production of galvanized steel destined for construction projects. Weak outlook comes amid diminishing expectations of a resurgence in the Chinese housing sector.

Additionally, US trade policy has softened demand, as uncertainty has dampened investor sentiment.

Although surpluses in the mined supply of zinc have narrowed, a significant amount of refined product remains in warehouses, which continues to contribute to an oversupply.

Data was gathered on December 24, 2025, using TradingView’s stock screener, and only zinc stocks with market caps greater than C$50 million at that time were considered. Read on to learn more about their operations and plans.

1. Teck Resources (TSX:TECK.A,TSX:TECK.B)

Market cap: C$31.25 billion
Share price: C$62.65

Teck Resources is a major global polymetallic miner, as well as one of the world’s top zinc producers. The company is headquartered in Vancouver, British Columbia.

The Canadian company produced 615,900 metric tons (MT) of zinc in concentrate in 2024, with 555,600 MT coming from its Red Dog zinc mine in Alaska, US. The remaining 60,300 MT came from Teck’s 22.5 percent share of zinc production from the Peru-based Antamina copper-zinc mine.

Teck’s total 2025 production guidance for the base metal is set in a range of 525,000 to 575,000 MT. As of September, the company’s zinc production for the year totaled 456,000 MT.

In addition to the sites mentioned, Teck owns the Trail operations, which it describes as “one of the world’s largest fully integrated zinc and lead smelting and refining complexes.” Located in BC, the Trail operations produced 256,000 MT of refined zinc in 2024, with 190,000 to 230,000 MT of the material expected in 2025.

In September, Teck agreed to combine with mining giant Anglo American (LSE:AAL,OTCQX:NGLOY) in a C$70 billion ‘merger of equals’ to create Anglo-Teck. The merged company would remain headquartered in Vancouver and become BC’s largest company ever.

Then on December 15, Canada’s federal government announced it had approved the deal after both companies committed to securing 4,000 Canadian jobs and spending C$4.5 billion over five years within Canada. The merger’s completion still requires approvals from other countries and regulatory reviews.

2. Foran Mining (TSX:FOM)

Market cap: C$2.62 billion
Share price: C$4.87

Foran Mining is a development company advancing its McIlvenna Bay project in Saskatchewan, Canada, toward production.

The property consists of 113 claims covering an area of 140,445 hectares near Flin Flon on Saskatchewan’s border with Manitoba.

A technical report from the project released in March 2025 demonstrated an indicated resource of 1.86 billion pounds of zinc at an average grade of 2.18 percent from 38.6 million metric tons of ore, plus an inferred resource of 260 million pounds at a grade of 2.6 percent from 4.5 million metric tons.

In December 2025, Foran announced that development on the project was 79 percent complete, advancing on schedule and on budget, and the company remained on track to begin commercial production in mid-2026. It also said that at the end of November, ore stockpiles had reached approximately 165,000 metric tons.

‘Pre-commissioning activities are well underway, and progress to date demonstrates the operational readiness of our team and infrastructure,’ Foran Executive Chairman and CEO Dan Myerson stated. ‘… 2026 (is) an important transition year for Foran as the Company moves into production, while advancing Phase 2 planning and continued exploration focused on unlocking district scale potential.’

3. Trilogy Metals (TSX:TMQ)

Market cap: C$1.14 billion
Share price: C$6.66

Trilogy Metals is focused primarily on copper, zinc and cobalt at its Alaskan Upper Kobuk projects, which are held by Ambler Metals, a joint venture operating company owned equally by Trilogy and South32 (ASX:S32,OTC Pink:SHTLF).

Its most advanced zinc project is the Arctic copper-zinc-lead-gold-silver volcanogenic massive sulfide project, which is in the feasibility stage and has proven and probable reserves of 43.44 million MT grading 3.12 percent zinc.

In addition, early stage 2023 field work at the company’s wholly owned Helpmejack project in Alaska’s Ambler belt outlined two target areas prospective for volcanogenic massive sulfide and shale-hosted zinc deposits.

Trilogy had been focusing on improving access to the region with its Amber Access project, but it was rejected by the US Bureau of Land Management under the Biden administration in June 2024 due to the impact the proposed road could have on the environment and communities in the region, which has seen little development.

However, the current Trump administration has enacted a series of executive and secretarial orders focusing on developing Alaska’s natural resources, leading to the reversal of the decision.

On October 24, the company announced that the Alaska Industrial Development and Export Authority had issued a right-of-way permit for the road, re-establishing federal authorization for the project.

‘The execution of these federal permits marks a pivotal milestone for the Ambler Road and the State of Alaska,’ Trilogy Metals President and CEO Tony Giardini said.

4. Fireweed Metals (TSXV:FWZ)

Market cap: C$579.91 million
Share price: C$2.73

Fireweed Metals is a critical metals company whose flagship Macmillan Pass zinc project is located in Canada’s Yukon. In 2023, the company acquired the Gayna River zinc project in the Northwest Territories, as well as the Mactung tungsten project, which is adjacent to Macmillan Pass and straddles the border between Yukon and the Northwest Territories.

In November 2023, the Fireweed team, led by Dr. Jack Milton, the firm’s vice president of geology, received the Association for Mineral Exploration’s H.H. ‘Spud’ Huestis Award for its work at the Macmillan Pass property.

In September 2024, after its largest regional exploration campaign ever at Macmillan Pass, the company released an updated resource estimate for the Tom and Jason deposits, as well as inaugural resource estimates for the Boundary zone and End zone deposits.

Fireweed launched its 2025 field program in early June, planned to include 12,000 meters of diamond drilling at Macmillan Pass and 3,000 meters at Gayna.

On September 23, Fireweed reported one of the best assays ever recorded at Macmillan Pass from a 115 meter step-out hole at the Tom South target, which hosted a 54.82 meter intersection grading 18.2 percent zinc, including an interval of 7.1 meters with 32.82 percent zinc.

Then, in an update on December 11, the company announced its inaugural drilling at Gayna intersected zinc mineralization, with a highlighted assay of 51.22 meters grading 4.4 percent zinc, including 24 meters with 7.3 percent.

‘Our first season of drilling at Gayna successfully intersected significant zinc and lead mineralization at the Intrepid target, validating the prospectivity of the project,’ Fireweed Metals President and CEO Ian Gibbs said.

5. Emerita Resources (TSXV:EMO)

Market cap: C$167.89 million
Share price: C$0.57

Emerita Resources has a portfolio of high-grade, large-scale polymetallic projects covering more than 26,000 combined hectares in Spain’s Iberian Pyrite Belt. The company’s flagship asset is the Iberian Belt West project, which hosts three massive sulfide deposits: La Infanta, La Romanera and El Cura.

Emerita released a resource estimate for Iberian Belt West in May 2023. It finished environmental baseline studies the following month, and completed supporting documentation for its mining license application in December 2023.

In July 2024, the Andalusian government granted Iberian Belt West a declaration of strategic interest, which will streamline the process of moving the project through development.

Phase 2 metallurgical testing results for the La Romanera and La Infanta deposits released in late 2024 show that commercial-grade copper, lead and zinc concentrates can be obtained from both deposits.

In March of this year, Emerita announced an updated resource estimate for Iberian Belt West, showing a 35 percent increase to the total indicated mineral resource tonnage and a 44 percent increase in total inferred mineral resource tonnage.

The total indicated resource stands at 547,000 metric tons of zinc, with an average grade of 2.88 percent zinc, from 18.96 million metric tons of ore, and the inferred resource is 221,000 metric tons from 6.8 million metric tons grading 3.25 percent zinc.

The company has continued to explore the site through the rest of 2025. On October 17, the company announced it had extended the El Cura deposit by 90 meters and highlighted one intersection measuring 4.1 meters with a grade of 8.5 percent zinc.

Securities Disclosure: I, Dean Belder, hold no direct investment interest in any company mentioned in this article.

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TORONTO, ON / ACCESS Newswire / December 31, 2025 / 55 North Mining Inc. (CSE:FFF,OTC:FFFNF)(FSE:6YF) (‘55 North‘ or the ‘Company‘) is pleased to announce the appointment of Wayne Parsons as Executive Chair of the Board, effective January 1, 2026.

Mr. Parsons brings over 20 years of experience in the investment business, having worked at BMO, RBC and most recently at National Bank Financial. He has since established a consulting practice focused on the mining sector and provides strategic advisory services to mining companies focused on capital markets strategy, financing execution and investor engagement. Mr. Parsons has served on a number of boards, most recently with Bunker Hill Mining Corp.

‘Wayne’s skills and experience are exactly what 55 North needs as we advance this project toward production,’ said Bruce Reid, Chief Executive Officer of 55 North Mining. ‘He is well connected globally and will be a tremendous help in connecting us with the right people to get this project financed. We met in the early days of Bunker Hill Mining, and when that project encountered challenges, Wayne stepped in, personally funded the recapitalization, and helped assemble the team to move it forward. His reputation will be highly valuable to our future success.’

The Company believes Mr. Parsons’ appointment significantly strengthens its leadership and positions 55 North to execute on its strategy of advancing the Last Hope Gold Project toward development and production.

About 55 North Mining Inc.

55 North Mining Inc. is a Canadian exploration and development company advancing its high-grade Last Hope Gold Project located in Manitoba, Canada.

FOR FURTHER INFORMATION, PLEASE CONTACT:

Mr. Bruce Reid
Chief Executive Officer
55 North Mining Inc.
Phone: 647-500-4495
bruce@mine2capital.ca

Mr. Vance Loeber
Corporate Development
Phone: 778-999-3530
cvl@tydewell.com

CAUTION REGARDING FORWARD-LOOKING INFORMATION

This news release of 55 North contains statements that constitute ‘forward-looking statements.’ Such forward-looking statements involve known and unknown risks, uncertainties and other factors that may cause the Company’s actual results, performance or achievements, or developments in the industry to differ materially from the anticipated results, performance or achievements expressed or implied by such forward-looking statements.

SOURCE: 55 North Mining Inc.

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(TheNewswire)

Prismo Metals Inc.

 

Vancouver, British Columbia TheNewswire – December 31st, 2025 Prismo Metals Inc. (‘Prismo’ or the ‘Company’) (CSE: PRIZ,OTC:PMOMF) (OTCQB: PMOMF) is pleased to announce that further to its news release December 3, 2025, the Company has proceeded with an upsized closing (the ‘Closing’) of its previously announced non-brokered private placement of units of the Company (‘Units’) at an issue price of $0.10 per Unit (the ‘Private Placement’). The Closing consisted in the issuance of 2,940,000 Units for gross proceeds of $294,000.

‘With the exception of one investor, every subscriber in this last closing is a new shareholder of Prismo,’ said Alain Lambert CEO of Prismo. ‘Our immediate priority is to undertake our fully funded drill program, as previously announced. This drill campaign will focus primarily on the historic Silver King mine site and will be for a minimum of about 1,000 meters. The objective is to test the upper half of the steeply dipping pipelike Silver King mineralized body as well as potential mineralization adjacent to the dense stockwork that was the focus of historic mining.’

The Company previously announced the first closing of the Private Placement on November 12, 2025 for aggregate gross proceeds of $1,745,000 and a second closing of the Private Placement on December 2, 2025 for aggregate gross proceeds of $165,000. Due to strong investor demand, the Company has now raised aggregate gross proceeds of $2,204,000 through the sale of an aggregate of 22,040,000 Units.

Each Unit consists of one common share in the capital of the Company (a ‘Share‘) and one common share purchase warrant of the Company (a ‘Warrant‘). Each Warrant entitles the holder to purchase one Share for a period of thirty-six (36) months from the date of issue at an exercise price of $0.175.

The Company intends to use the net proceeds of the Private Placement primarily for drilling at its Silver King project and for general corporate purposes. There may be circumstances, however, where, for sound business reasons, a reallocation of funds may be necessary. The Company expects to accept additional subscriptions of Units from new shareholders in the coming days for an approximate amount of $75,000.

The Units issued pursuant to the Closing are subject to a four-month hold period from the closing date of the Closing under applicable Canadian securities laws, in addition to such other restrictions as may apply under applicable securities laws of jurisdictions outside Canada.

In connection with the Closing, the Company issued an aggregate of 185,200 finder’s warrants (the ‘Finder’s Warrants’) and paid finder’s commissions of $18,520 to a certain qualified finder. Each Finder’s Warrant is exercisable for a period of twenty-four (24) months from the date of issuance to purchase one Share at a price of $0.10. In addition, the Company paid a cash fee of $7,000 to a financial advisor.

The securities being issued in connection with the Closing have not been and will not be registered under the U.S. Securities Act and may not be offered or sold in the United States, or to, or for the account or benefit of, U.S. persons or persons in the United States, absent registration or an applicable exemption from the registration requirements. This press release shall not constitute an offer to sell or the solicitation of an offer to buy nor shall there be any sale of the securities in any State in which such offer, solicitation or sale would be unlawful.

About Prismo Metals Inc.

Prismo (CSE: PRIZ,OTC:PMOMF) is a mining exploration company focused on advancing its Silver King, Ripsey and Hot Breccia projects in Arizona and its Palos Verdes silver project in Mexico.

Please follow PrismoMetals on Twitter, Facebook, LinkedIn, Instagram, and YouTube

Prismo Metals Inc.

1100 – 1111 Melville St., Vancouver, British Columbia V6E 3V6 Phone: (416) 361-0737

 

Contact:

Alain Lambert, Chief Executive Officer alain.lambert@prismometals.com

Gordon Aldcorn, President gordon.aldcorn@prismometals.com

 

Neither the Canadian Securities Exchange nor its Market Regulator (as that term is defined in the policies of the Canadian Securities Exchange) accepts responsibility for the adequacy or accuracy of this release.

 

Cautionary Note Regarding Forward-Looking Information

This release includes certain statements and information that may constitute forward-looking information within the meaning of applicable Canadian securities laws. Forward-looking statements relate to future events or future performance and reflect the expectations or beliefs of management of the Company regarding future events. Generally, forward-looking statements and information can be identified by the use of forward-looking terminology such as ‘intends’ or ‘anticipates’, or variations of such words and phrases or statements that certain actions, events or results ‘may’, ‘could’, ‘should’, ‘would’ or ‘occur’. This information and these statements, referred to herein as ‘forward-looking statements’, are not historical facts, are made as of the date of this news release and include without limitation, statements regarding discussions of future plans, estimates and forecasts and statements as to management’s expectations and intentions with respect to, among other things: the timing, costs and results of drilling at Silver King; the intended use of any proceeds raised under the Closing; and the completion of an additional tranche.

These forward-looking statements involve numerous risks and uncertainties, and actual results might differ materially from results suggested in any forward-looking statements. These risks and uncertainties include, among other things: the potential inability of the Company to utilize the anticipated proceeds of the Private Placement as anticipated; the potential inability of the Company to complete an additional tranche on the terms disclosed, or at all; and those risks set out in the Company’s public disclosure record on SEDAR+ (www.sedarplus.com) under the Company’s issuer profile.

In making the forward-looking statements in this news release, the Company has applied several material assumptions, including without limitation, that the Company will use the proceeds of the Closing as currently anticipated and on the timeline currently expected; and that the Company will complete an additional tranche.

Although management of the Company has attempted to identify important factors that could cause actual results to differ materially from those contained in forward-looking statements or forward-looking information, there may be other factors that cause results not to be as anticipated, estimated or intended. There can be no assurance that such statements will prove to be accurate, as actual results and future events could differ materially from those anticipated in such statements. Accordingly, readers should not place undue reliance on forward-looking statements and forward- looking information. Readers are cautioned that reliance on such information may not be appropriate for other purposes. The Company does not undertake to update any forward-looking statement, forward-looking information or financial outlook that are incorporated by reference herein, except in accordance with applicable securities laws. We seek safe harbor.

 

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VANCOUVER, BRITISH COLUMBIA / ACCESS Newswire / December 31, 2025 / CoTec Holdings Corp. (TSXV:CTH,OTC:CTHCF)(OTCQB:CTHCF) (‘CoTec’ or the ‘Company’) is pleased to note MagIron LLC’s (‘MagIron’) press release dated December 31, 2025, following its prior press release dated December 19, 2025. CoTec owns 16.5% of the equity in MagIron on a fully diluted basis.

MagIron announced that it has successfully completed the acquisition of the pellet plant located near Reynolds, Indiana (‘Reynolds Pellet Plant’) from the Receivership Estate of Altos Hornos De Mexico, S.A.B De C.V. (the ‘Acquisition’) on schedule and in accordance with the Asset Purchase Agreement (‘APA’).

Larry Lehtinen, CEO of MagIron commented: ‘The completion of this transaction marks a significant milestone for MagIron. We now look forward to implementing our restart strategy and bringing significant investment and job creation to both Minnesota and Indiana.’

Julian Treger, CoTec CEO commented: ‘The Reynolds Pellet Plant is a modern straight grate, past producing, restart-ready pelletizer benefitting from approximately $440 million of prior investment. The completion of its acquisition enables MagIron to now focus on the execution of its strategy to become a fully integrated DR pellet producer to America’s fast growing Electric Arc Furnace steel industry and pursuing the development of merchant pig iron facilities. CoTec is very supportive of this strategy and believes that, if successful, MagIron could become a significant contributor to the USA steel industry.’

For more information on this press release, please visit https://magironusa.com

About CoTec

CoTec Holdings Corp. (TSX-V:CTH)(OTCQB:CTHCF) is redefining the future of resource extraction and recycling. Focused on rare earth magnets and strategic materials, CoTec integrates breakthrough technologies with strategic assets to unlock secure, sustainable, and low-cost supply chains for the United States and its allies.

CoTec’s mission is clear: accelerate the energy transition while strengthening U.S. economic and national security. By investing in and deploying disruptive technologies, the Company delivers capital-efficient, scalable solutions that transform marginal assets, tailings, waste streams, and recycled products into high-value critical minerals.

From its HyProMag USA magnet recycling joint venture in Texas, to iron tailings reprocessing in Québec, to next-generation copper and iron solutions backed by global majors, CoTec is building a diversified portfolio with long-term growth, rapid cash flow potential, and high barriers to entry. The result is a game-changing platform at the intersection of technology, sustainability, and strategic materials.

For more information, please visit www.cotec.ca

For further information, please contact:

Braam Jonker – (604) 992-5600
Chief Financial Officer

Forward-Looking Information Cautionary Statement

Statements in this press release regarding the Company and its investments which are not historical facts are ‘forward-looking statements’ which involve risks and uncertainties, including statements relating to the Company’s interest in MagIron, the completion of the Acquisition, the potential restart of the MagIron operations, the MagIron strategy, including a potential development of pig iron facilities and management’s expectations with respect to its current and potential future investments, and the benefits to the Company which may be implied from such statements. Since forward-looking statements address future events and conditions, by their very nature, they involve inherent risks and uncertainties. Actual results in each case could differ materially from those currently anticipated in such statements, due to known and unknown risks and uncertainties affecting the Company, including but not limited to resource and reserve risks; environmental risks and costs; labor costs and shortages; uncertain supply and price fluctuations in materials; increases in energy costs; labor disputes and work stoppages; leasing costs and the availability of equipment; heavy equipment demand and availability; contractor and subcontractor performance issues; worksite safety issues; project delays and cost overruns; extreme weather conditions; and social and transport disruptions. For further details regarding risks and uncertainties facing the Company please refer to ‘Risk Factors’ in the Company’s filing statement dated April 6, 2022, a copy of which may be found under the Company’s SEDAR profile at www.sedar.com. The Company assumes no responsibility to update forward-looking statements in this press release except as required by law. Readers should not place undue reliance on the forward-looking statements and information contained in this news release and are encouraged to read the Company’s continuous disclosure documents which are available on SEDAR at www.sedarplus.ca.

Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this news release.

SOURCE: CoTec Holdings Corp.

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Here’s a quick recap of the crypto landscape for Monday (December 29) as of 9:00 p.m. UTC.

Get the latest insights on Bitcoin, Ether and altcoins, along with a round-up of key cryptocurrency market news.

Bitcoin and Ether price update

Bitcoin (BTC) was priced at US$87,107.03, down by 0.4 percent over 24 hours.

Bitcoin price performance, December 29, 2025.

Bitcoin price performance, December 29, 2025.

Chart via TradingView.

BTC’s spot market shows mild selling pressure with a slight price decline, neutral momentum from the RSI at 45.40 and a low positive funding rate of 0.008 percent, suggesting limited bullish aggression in derivatives.

Mostly long liquidations totaling US$1.67 million over four hours leading up to the end of the trading day, alongside a 0.35 percent drop in open interest to US$57.54 billion, point to deleveraging among overextended buyers, while thin holiday trading volumes amplify small moves.

The data signals continued consolidation, holding the key support around US$86,000, despite a weekly dip. Overall, traders appear sidelined with bearish short-term momentum.

Linh Tran, a senior market Analyst at XS.com, suggests that BTC is entering a phase of stability and renewed accumulation in Q1 2026, rather than a strong growth phase at the beginning of the year.

“However, recent data also indicate that ETF flows are no longer consistently strongly net positive as in the early phase of the cycle, but have become more volatile, with some weeks even recording net outflows amid portfolio rebalancing and holiday-related liquidity conditions.

In my view, this does not imply that Bitcoin’s long-term trend has turned bearish, but rather suggests that institutional demand in Q1 2026 is likely to be more selective and cautious, instead of acting as a catalyst for a sharp breakout in Bitcoin prices.”

Regulatory progress, BTC’s correlation as a risk asset to the US equity market, and geopolitical risks will also act as catalysts.

“Bitcoin’s underlying structure is significantly more solid than in previous cycles, thanks to institutional participation and broader acceptance within the financial system. If institutional flows return, the regulatory and geopolitical environment becomes more supportive, and the Fed’s policy stance begins to signal that rate cuts are approaching earlier in the year, this combination could create an ideal environment for Bitcoin to recover and reclaim the US$100,000 level.”

Ether (ETH) was priced at US$$2,928.18, down by 0.1 percent over the last 24 hours.

Altcoin price update

  • XRP (XRP) was priced at US$1.85, down by 0.7 percent over 24 hours.
  • Solana (SOL) was trading at US$122.97, down by 0.3 percent over 24 hours.

Today’s crypto news to know

Strategy announces latest BTC purchase

Strategy (NASDAQ:MSTR) announced its latest BTC purchase of 2025, adding 1,229 BTC between December 22-28 for a purchase price of US$108.8 million, according to a Form 8-K filed on Monday.

The purchase brings Strategy’s total Bitcoin holdings to 672,497 BTC.

Chinese banks to pay interest on digital yuan wallets from January 2026

China’s central bank, the People’s Bank of China (PBOC), is updating its digital yuan (e-CNY) rules effective January 1, 2026, to let commercial banks pay interest on users’ wallet balances, according to a PBOC-affiliated China Financial Times article published on Monday. This shifts the e-CNY from just a digital cash replacement to something more like a bank deposit, aiming to boost everyday use after years of slow adoption.

PBOC deputy governor Lu Lei explained the changes in the article: ‘Looking ahead, the choice of business and technology models for the digital yuan will adhere to the fundamental principle of meeting the needs of the real economy. It will adopt a principle of inclusiveness and prudent selection regarding the development of account-based and value-based digital currencies, and promote the digital yuan to meet the needs of different scenarios and different business entities.’

ALT5 Sigma’s auditor switch draws regulatory heat

Nasdaq-listed crypto firm ALT5 Sigma (NASDAQ:ALTS) is under renewed scrutiny after it emerged that its newly appointed auditor is currently barred from conducting audits due to an inactive firm license.

According to the Financial Times, the issue surfaced after the company missed its third-quarter filing deadline and hastily replaced its previous auditor earlier this month.

The new firm, Victor Mokuolu CPA PLLC, does not hold an active Texas firm license, effectively preventing it from issuing any audit opinions under state rules.

While the firm’s founder renewed his personal CPA license in late August, state records show the firm itself remains unlicensed as of late December. ALT5 Sigma told the Financial Times that no reviews or audits will be issued until the licensing issue is resolved, with a mandatory peer review now underway and expected to conclude by the end of January.

Russia floats Bitcoin mining at occupied Ukrainian nuclear plant

Officials at the Russia-controlled Zaporizhzhia nuclear power plant say they are prepared to supply electricity to Bitcoin miners, but only if a broader peace deal involving Ukraine is reached.

The plant, seized by Russian forces in March 2022 and now operated by state-owned Rosenergoatom, could power crypto mining farms alongside civilian infrastructure, representatives told Russian media.

The comments followed remarks by President Vladimir Putin that US-Russia discussions have expanded beyond security to include economic proposals tied to the facility’s output. Putin said American counterparts had expressed interest in using the plant’s electricity both for cryptocurrency mining and for supplying power to Ukraine.

XRP and Solana defy crypto fund outflows, Bitcoin and Ether slide

Crypto investment products bled US$446 million in net outflows last week, extending the sector’s post-October slump and pushing cumulative withdrawals since the sharp market downturn to US$3.2 billion.

According to the recent Digital Asset Fund Flows Weekly report by CoinShares, Bitcoin and Ethereum bore the brunt of the selling. In contrast, XRP and Solana stood out as rare bright spots, pulling in US$70.2 million and US$7.5 million in weekly inflows, respectively.

By late December, XRP ETFs had logged more than US$1 billion in cumulative inflows, while Solana ETFs had surpassed US$750 million.

Securities Disclosure: I, Meagen Seatter, hold no direct investment interest in any company mentioned in this article.

Securities Disclosure: I, Giann Liguid, hold no direct investment interest in any company mentioned in this article.

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TORONTO, ON / ACCESS Newswire / December 31, 2025 / NextSource Materials Inc. (TSX:NEXT,OTC:NSRCF)(OTCQB:NSRCF) (‘NextSource’ or the ‘Company’) is pleased to announce the results of the Annual Meeting of Shareholders of the Company (the ‘Meeting’) held virtually at 8:00 AM (Toronto time) on December 30, 2025.

AGM Results

The final voting results of the Meeting are set out below:

  1. Election of Directors. The Company’s shareholders elected each of the nominees as directors to serve until the next annual meeting of shareholders, or until their respective successors are elected or appointed. The following table sets forth the voting results with respect to the election of directors:

Nominee

For

Against

Sir Mick Davis

99.6%

0.4%

Hanré Rossouw

99.5%

0.5%

Christopher Kruba

99.7%

0.3%

Ian Pearce

99.7%

0.3%

Craig Scherba

99.5%

0.5%

Brett Whalen

99.5%

0.5%

2. Appointment of Auditor. The Company’s shareholders approved the appointment of PricewaterhouseCoopers LLP, Chartered Professional Accountants, as the Company’s auditors for the fiscal year ending June 30, 2026 and that the Board of Directors is authorized to fix their remuneration. The following table sets forth the voting results with respect to the appointment of PricewaterhouseCoopers LLP:

For

Withheld

99.9%

0.1%

A total of 101,161,308 common shares equivalent to 54.7% of the common shares entitled to vote were represented in person or by proxy at the Meeting.

ABOUT NextSource Materials Inc.

NextSource Materials Inc. is a battery materials company based in Toronto, Canada that is intent on becoming a vertically integrated global supplier of battery materials through the mining and value-added processing of graphite and other minerals.

The Company’s Molo graphite project in Madagascar is one of the largest known and highest-quality graphite resources globally, and the only one with SuperFlake® graphite. The Molo mine has begun production through Phase 1 mine operations.

The Company is also developing a significant downstream graphite value-add business through the staged rollout of Battery Anode Facilities (BAF) capable of large-scale production of coated, spheronized and purified graphite for direct delivery to battery and automotive customers, in a fully transparent and traceable manner. The Company is now in the process of developing its first BAF in the UAE.

NextSource Materials is listed on the Toronto Stock Exchange under the symbol ‘NEXT’ and on the OTCQB under the symbol ‘NSRCF’.

For further information about NextSource Materials, please visit our website at www.nextsourcematerials.com or contact us at +1.416.364.4911 or email Brent Nykoliation, Executive Vice President at brent@nextsourcematerials.com.

CAUTIONARY NOTE

This press release contains statements that may constitute ‘forward-looking information’ or ‘forward-looking statements’ within the meaning of applicable Canadian and United States securities legislation. Readers are cautioned not to place undue reliance on forward-looking information or statements. Forward looking statements and information are frequently characterized by words such as ‘plan’, ‘expect’, ‘project’, ‘intend’, ‘believe’, ‘anticipate’, ‘estimate’, ‘potential’, ‘possible’ and other similar words, or statements that certain events or conditions ‘may’, ‘will’, ‘could’, or ‘should’ occur. Forward- looking statements include any statements regarding, among others, reaching nameplate production capacity and the rollout of Battery Anode Facilities including the capabilities and the timing and economics thereof. These statements are based on current expectations, estimates and assumptions that involve a number of risks, which could cause actual results to vary and, in some instances, to differ materially from those anticipated by the Company and described in the forward-looking statements contained in this press release. No assurance can be given that any of the events anticipated by the forward-looking statements will transpire or occur or, if any of them do so, what benefits the Company will derive there from. The forward-looking statements contained in this news release are made as at the date of this news release and the Company does not undertake any obligation to update publicly or to revise any of the forward-looking statements, whether because of new information, future events or otherwise, except as may be required by applicable securities laws. Although the forward-looking statements contained in this news release are based on what management believes are reasonable assumptions, the Company cannot assure investors that actual results will be consistent with them. These forward-looking statements are made as of the date of this news release and are expressly qualified in their entirety by this cautionary statement. Subject to applicable securities laws, the Company does not assume any obligation to update or revise the forward-looking statements contained herein to reflect events or circumstances occurring after the date of this news release.

SOURCE: NextSource Materials Inc.

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Sankamap Metals Inc. (CSE: SCU) (‘Sankamap’ or the ‘Company’) the Company and its auditor continue to work diligently toward the completion and filing of the Company’s annual audited financial statements and management’s discussion and analysis for the fiscal year ended June 30, 2025 (the ‘Required Filings’). The Company has applied to the Alberta Securities Commission for an extension of the Management Cease Trade Order (‘MCTO’), however, there can be no assurance that a further extension will be granted. The additional delay in completing the Required Filings is primarily due to the auditor awaiting the receipt of certain required information from government authorities in Solomon Islands, as well as timing constraints associated with the holiday period. The Company estimates that approximately 90% of the audit work has been completed.

The Required Filings were due to be filed by October 28, 2025. In connection with the anticipated delays in making the Required Filings, the Company made an application for a Management Cease Trade Order (‘MCTO‘) under National Policy 12-203 Management Cease Trade Orders (‘NP 12-203‘) to the Alberta Securities Commission, as principal regulator for the Company, and the MCTO was issued on October 29, 2025. The MCTO restricts all trading by the Company’s CEO and CFO in securities of the Company, whether direct or indirect. The MCTO does not affect the ability of persons who are not directors, officers or insiders of the Company to trade their securities. The MCTO will remain in effect until the Required Filings are filed or until it is revoked or varied.

The Company expects to proceed with the filing of its interim first-quarter financial statements shortly after the Required Filings have been completed and submitted.

The Company confirms that it intends to satisfy the provisions of the alternative information guidelines described in NP 12-203 by issuing bi-weekly default status reports in the form of a news release until it meets the Required Filings requirement. The Company has not taken any steps towards any insolvency proceeding and the Company has no material information relating to its affairs that has not been generally disclosed.

For further information with respect to the MCTO, please refer to the Company’s news releases dated October 21, 2025, November 4, 2025, November 18, 2025, December 3, 2025 and December 17, 2025, available for viewing on the Company’s SEDAR+ profile at www.sedarplus.ca.

About Sankamap Metals Inc.

Sankamap Metals Inc. (CSE: SCU) is a Canadian mineral exploration company dedicated to the discovery and development of high-grade copper and gold deposits through its flagship Oceania Project, located in the South Pacific. The Company’s fully permitted assets are strategically positioned in the Solomon Islands, along a prolific geological trend that hosts major copper-gold deposits; including Newcrest’s Lihir Mine, with a resource of 71.9 million ounces of gold¹ (310 Mt containing 23 Moz Au at 2.3 g/t P+P, 520 Mt containing 39 Moz Au at 2.3 g/t indicated, 81 Mt containing 5 Moz Au at 1.9 g/t measured, 61 Mt containing 4.9 Moz Au at 2.3 g/t Inferred).

Exploration is actively advancing at both the Kuma and Fauro properties, part of Sankamap’s Oceania Project in the Solomon Islands. Historical work has already highlighted the mineral potential of both sites, which lie along a highly prospective copper and gold-bearing trend, suggesting the possibility of further, yet-to-be-discovered deposits.

At Kuma, the property is believed to host an underexplored and largely untested porphyry copper-gold (Cu-Au) system. Historical rock chip sampling has returned consistently elevated gold values above 0.5 g/t Au, including a standout sample assaying 11.7% Cu and 13.5 g/t Au2; underscoring the area’s significant potential.

At Fauro, particularly at the Meriguna Target, historical trenching has returned highly encouraging results, including 8.0 meters at 27.95 g/t Au and 14.0 meters at 8.94 g/t Au3. Complementing these results are exceptional grab sample assays, including historical values of up to 173 g/t Au3, along with recent sampling by Sankamap at the Kiovakase Target, which returned numerous high-grade copper values, reaching up to 4.09% Cu. In addition, limited historical shallow drilling intersected 35.0 meters at 2.08 g/t Au3, further underscoring the property’s strong mineral potential and the merit for continued exploration. With a commitment to systematic exploration and a team of experienced professionals, Sankamap aims to unlock the untapped potential of underexplored regions and create substantial value for its shareholders. For more information, please refer to SEDAR+ (www.sedarplus.ca), under Sankamap’s profile.

1.Newcrest Technical Report, 2020 (Lihir: 310 Mt containing 23 Moz Au at 2.3 g/t P+P, 520 Mt containing 39 Moz Au at 2.3 g/t indicated, 81 Mt containing 5 Moz Au at 1.9 g/t measured, 61 Mt containing 4.9 Moz Au at 2.3 g/t Inferred)

2. Historical grab, soil and BLEG samples from SolGold Kuma Review June 2015, and SolGold plc Annual Report 2013/2012

3. September 2010-June 2012 press releases from Solomon Gold Ltd. and SolGold Fauro Island Summary Technical Info 2012

QP Disclosure

The technical content for the Oceania Project in this news release has been reviewed and approved by John Florek, M.Sc., P.Geol., a Qualified Person in accordance with CIM guidelines. Mr. John Florek is in good standing with the Professional Geoscientists of Ontario (Member ID:1228) and a director and officer of the Company.

ON BEHALF OF THE BOARD OF DIRECTORS

s/ ‘John Florek’
John Florek, M.Sc., P.Geol
Chief Executive Officer
Sankamap Metals Inc.

Contact:
John Florek, CEO
T: (807) 228-3531
E: johnf@sankamap.com

The Canadian Securities Exchange has not approved nor disapproved this press release.

Forward-Looking Statements

Certain statements made and information contained herein may constitute ‘forward-looking information’ and ‘forward-looking statements’ within the meaning of applicable Canadian and United States securities legislation. These statements and information are based on facts currently available to Sankamap and there is no assurance that the actual results will meet management’s expectations. Forward-looking statements and information may be identified by such terms as ‘anticipates,’ ‘believes,’ ‘targets,’ ‘estimates,’ ‘plans,’ ‘expects,’ ‘may,’ ‘will,’ ‘could’ or ‘would.’

This press release contains forward-looking statements, including, but not limited to, statements regarding management’s expectations about obtaining the MCTO and completing the Required Filings within the anticipated timeline. Forward-looking statements are subject to various risks, uncertainties, and other factors that could cause actual results or events to differ materially from those expressed or implied by such statements. Sankamap does not undertake any obligation to update forward-looking statements or information, except as required by applicable securities laws. For more information on the Company, investors should review the Company’s continuous disclosure filings that are available at www.sedarplus.ca.

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The NASDAQ Biotechnology Index (INDEXNASDAQ:NBI) is trading at three year highs despite market volatility, responding to breakthrough innovations and increased deals involving NASDAQ biotech stocks.

After dropping to a low of 3,637.05 in October 2023, the index climbed to a nearly three year peak of 4,954.813 on September 19, 2024. While the index pulled back to 4,530.69 in August 2025, it staged a robust recovery in the second half of the year, closing at 5,766.59 on December 29, 2025, a gain of approximately 34 percent for the year.

The top NASDAQ biotech stocks have seen sizeable share price increases over the past year. For those interested in investing in biotech companies, the best-performing small-cap biotech stocks are outlined below.

Data was gathered on December 29, 2025, using TradingView’s stock screener. Small-cap biotech stocks with market caps between US$50 million and US$500 million at that time were considered for this list.

1. SELLAS Life Sciences Group (NASDAQ:SLS)

Year-to-date gain: 210.19 percent
Market cap: US$477.18 million
Share price: US$3.35

SELLAS Life Sciences Group is a late-stage biopharmaceutical company focused on novel cancer immunotherapies. The company’s approach involves ‘teaching’ the immune system to recognize and kill cancer cells by targeting specific proteins that are overexpressed in tumors.

Its flagship asset is galinpepimut-S (GPS), a vaccine-like immunotherapy for patients with acute myeloid leukemia (AML) who are in remission but at high risk of relapse. Its secondary asset, SLS009, is a highly selective CDK9 inhibitor currently showing promise in Phase 2 trials for various blood cancers.

The company’s stock price surged on December 29 after SELLAS shared an update on the Phase 3 REGAL trial evaluating GPS as a maintenance therapy in patients with AML. The trial is designed as a blind survival study, with the end point triggered on the 80th patient death.

In the update, the company reported that 72 deaths had occurred as of December 26. Because it is taking longer than expected for the trial to complete, which was previously anticipated to happen before the end of 2025, investors are speculating that the patients in the trial are living significantly longer than the historical average.

2. IO Biotech (NASDAQ:IOBT)

Year-to-date gain: 129.47 percent
Market cap: US$144.28 million
Share price: US$2.16

IO Biotech is developing immune-modulating therapeutic cancer vaccines based on its T-win technology platform, designed to activate T cells to target both tumor cells and the immune-suppressive cells.

The clinical-stage biopharmaceutical company’s lead cancer vaccine candidate is IO102-IO103, which has the brand name Cylembio. IO102-IO103 has breakthrough therapy designation from the US Food and Drug Administration (FDA) when used in combination with Merck’s (NYSE:MRK) anti-PD-1 therapy Keytruda for the treatment of advanced melanoma based on positive Phase 1/2 first line metastatic melanoma data.

The candidate reached a major milestone in August 2025 with the readout of its pivotal Phase 3 trial of IO102-IO103 with Keytruda for treating advanced melanoma. While the vaccine combined with Keytruda showed a significant survival benefit — reaching 19.4 months of progression-free survival compared to 11 months for Keytruda alone — it narrowly missed the strict statistical significance threshold.

Following a December meeting with the FDA to discuss a path forward for Cylembio, IO Biotech ended the year focused on a new registrational trial to address the Phase 3 miss and securing further funding to extend its operations into 2026.

Throughout 2025, the company continued to expand its pipeline. In November, it presented new pre-clinical data for IO112 targeting arginase 1 and for IO170 targeting transforming growth factor.

3. Tiziana Life Sciences (NASDAQ:TLSA)

Year-to-date gain: 124.64 percent
Market cap: US$184.22 million
Share price: US$1.55

Tiziana Life Sciences is a clinical-stage biopharma which is developing therapies for autoimmune and inflammatory diseases, degenerative diseases and cancer-related to the liver. Its pipeline of candidates is built on its patented drug delivery technology that provides a possible alternative to intravenous delivery.

Tiziana’s lead candidate is intranasal foralumab, a fully human anti-CD3 monoclonal antibody, which it is currently studying for treatment of a range of conditions.

In March, the company filed an investigational new drug application with the FDA for a Phase 2 clinical trial in amyotrophic lateral sclerosis (ALS), which is supported by the ALS Association. The Phase 2 trial is slated to begin in January 2026. Tiziana also began dosing patients in a Phase 2a trial for multiple system atrophy in August.

In April, John Hopkins University and the University of Massachusetts commenced dosing of the biotech company’s intranasal foralumab in Phase 2 trials for patients with non-active secondary progressive multiple sclerosis (MS). On May 7, the company shared positive results from the use of its lead candidate in improving the quality of life for patients with that form of MS.

Tiziana is also studying the use of intranasal foralumab for treating moderate Alzheimer’s disease. On May 9, it announced that PET scans of a patient with moderate Alzheimer’s showed a significant reduction in microglia activation associated with neuroinflammation after three months of treatment.

On July 21, the company announced an ‘unexpected discovery’ following immunologic analysis of the patient with Alzheimer’s disease: ‘The analysis revealed an increase in phagocytosis markers in classical monocytes, suggesting that nasal foralumab may enhance their ability to clear amyloid plaques. This unexpected effect may open new avenues for treating Alzheimer’s Disease by targeting both inflammation and amyloid accumulation.’

The company dosed the first patient in its randomized Phase 2 Alzheimer’s trial in December.

To end the year, Tiazana submitted a comprehensive safety report to the FDA documenting over 37 patient-years of treatment with no serious drug-related adverse events across its studies.

4. Spero Therapeutics (NASDAQ:SPRO)

Year-to-date gain: 119.05 percent
Market cap: US$129.58 million
Share price: US$2.30

Spero Therapeutics is developing novel treatments for rare diseases and multi-drug resistant bacterial infections with high unmet need.

The company’s lead drug candidate is tebipenem pivoxil hydrobromide (HBr), a late-stage development asset developed in collaboration with pharma giant GSK (NYSE:GSK). GSK has an exclusive license agreement to commercialize the drug candidate in most markets.

Tebipenem HBr is an oral carbapenem developed to treat complicated urinary tract infections (cUTIs), including pyelonephritis. The FDA granted tebipenem HBr qualified infectious disease product and fast-track designations.

Spero’s stock surged 245 percent on May 28 to reach US$2.35 after the company reported that its Phase 3 trial evaluating tebipenem HBr for treating cUTIs met its primary endpoint and stopped early for efficacy.

On December 19, GSK officially filed the new drug application resubmission to the FDA for tebipenem HBr for treating cUTIs supported by the Phase 3 results. This filing triggered a US$25 million milestone payment to Spero that is expected in Q1 2026.

5. OKYO Pharma (NASDAQ:OKYO)

Year-to-date gain: 60.50 percent
Market cap: US$74.85 million
Share price: US$1.91

OKYO Pharma is a clinical-stage biopharma company developing therapies for the treatment of neuropathic corneal pain and dry eye disease. Its lead candidate is urcosimod, a non-steroidal anti-inflammatory and non-opioid analgesic.

OKYO is currently evaluating urcosimod for the treatment of neuropathic corneal pain. The treatment received fast track designation from the FDA in May after the company ended its Phase 2 clinical trial early to analyze data.

On July 17, the company posted strong top-line data from the Phase 2 trial and stated it is planning a meeting with the FDA to discuss next steps for its lead drug candidate. The following day, OKYO received US$1.9 million in non-dilutive funding to support its clinical development of urcosimod.

In September, OKYO announced a 120 patient, multi-center multiple ascending dose clinical trial designed to identify the optimal dose for Phase 3 registration.

A scientific breakthrough followed on December 11, when new imaging data revealed that urcosimod may actually help restore corneal nerve structure, showing median increases in nerve fiber count and length, while those in the placebo group saw median decreases for both.

Securities Disclosure: I, Meagan Seatter, hold no direct investment interest in any company mentioned in this article.

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